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Anaemia

As prevsiouly discussed, the blood oxygen content is directly proportional to the haemoglobin concentration and, consequently, anaemia (and polycythaemia) has largely predictable effects on the ODC. In simple terms, a reduction of haemoglobin concentration to half of the normal value is accompanied by a similar reduction in arterial oxygen content with no (or very little) change in % mylol eÅŸleÅŸme hilesi saturation or P_aO2 (figure 2). Despite reduced oxygen carriage by the blood, tissue oxygen consumption is likely to show little change and is maintained by several compensatory factors, including higher cardiac output and greater extraction of oxygen by the tissues. Consequently, the blood “reserve” of oxygen is diminished and the venous oxygen content, saturation and partial pressure are all less than normal.

5 g ? dL ?1 compared to normal haemoglobin concentration of 15 g ? dL ?1 . When oxygen content is plotted against P_O2 the curve in anaemia is scaled down by fifty%, reflecting the halving of oxygen carrying capacity (dissolved oxygen is ignored); when Sa_O2 is plotted the anaemic and normal curves are superimposed.

Haemoglobinopathies

A large number of genetically determined abnormal haemoglobins have been described, one of the more familiar being HbS which is found in patients with sickle cell disease. In individuals with a haemoglobinopathy, the abnormal molecules comprise a variable proportion of the total haemoglobin and consequently, the effects are similarly variablepared to the normal adult HbA, the abnormal haemoglobin molecules are associated with shifts of the ODC which can be either to the right (low oxygen affinity haemoglobins) or to the left (high oxygen affinity haemoglobins). Continue reading “ODCs from inside the a theoretic topic that have anaemia and you will haemoglobin (Hb) intensity of 7”

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